Parathyroid hormone regulates hydroxyvitamin D 3 hydroxylase mRNA by altering its stability. Parathyroid hormone activates the orphan nuclear receptor Nurr1 to induce FGF23 transcription. Parathyroid hormone stimulates receptor activator of NFkappa B ligand and inhibits osteoprotegerin expression via protein kinase A activation of cAMP-response element-binding protein.
Bone DOI: Molecular and cellular mechanisms of the anabolic effect of intermittent PTH. Transcription in the osteoblast: regulatory mechanisms utilized by parathyroid hormone and transforming growth factor-beta.
Endocrinology DOI: Transactivation of the epidermal growth factor receptor mediates parathyroid hormone and prostaglandin F2 alpha-stimulated mitogen-activated protein kinase activation in cultured transgenic murine osteoblasts. Mol Endocrinol DOI: Extracellular signal-regulated kinase activation by parathyroid hormone in distal tubule cells. J Cell Sci Pt 6 : — J Clin Invest : — Bone 25 : — Oxford University Press is a department of the University of Oxford. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide.
Sign In or Create an Account. Sign In. Advanced Search. Search Menu. Article Navigation. Close mobile search navigation Article Navigation. Volume Article Contents Abstract. Materials and Methods. Singh , A. Oxford Academic. Stern, Ph. Cite Cite A. Select Format Select format. Permissions Icon Permissions. Abstract PTH, a major regulator of bone remodeling and a therapeutically effective bone anabolic agent, stimulates several signaling pathways in osteoblastic cells.
Open in new tab Download slide. Signal transduction pathways mediating parathyroid hormone regulation of osteoblastic gene expression. Google Scholar Crossref. Search ADS. PTH elevates inositol polyphosphates and diacylglycerol in a rat osteoblast-like cell line. Google Scholar PubMed. Rhodopsin-family receptors associate with small G proteins to activate phospholipase D. The small GTP-binding protein Rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors.
Role of small GTP binding proteins in the growth-promoting and antiapoptotic actions of gastrin. Anti-apoptotic mechanism and reduced expression of phospholipase D in spontaneous and Fas-stimulated apoptosis of human neutrophils.
A simple method for the isolation and purification of total lipids from animal tissues. The G-protein G 13 but not G 12 mediates signaling from lysophosphatidic acid receptor via epidermal growth factor receptor to Rho. Dissociation of LPA-induced cytoskeletal contraction from stress fiber formation by differential localization of RhoA. The small GTP-binding protein, Rho p21, is involved in bone resorption by regulating cytoskeletal organization in osteoclasts.
Rho-A is critical for osteoclast podosome organization, motility, and bone resorption. Increased bone formation by prevention of osteoblast apoptosis with parathyroid hormone. There is no doubt that chronic secretion or continuous infusion of parathyroid hormone leads to decalcification of bone and loss of bone mass.
However, in certain situations, treatment with parathyroid hormone can actually stimulate an increase in bone mass and bone strength. This seemingly paradoxical effect occurs when the hormone is administered in pulses e. Inadequate production of parathyroid hormone - hypoparathyroidism - typically results in decreased concentrations of calcium and increased concentrations of phosphorus in blood.
Common causes of this disorder include surgical removal of the parathyroid glands and disease processes that lead to destruction of parathyroid glands. The resulting hypocalcemia often leads to tetany and convulsions, and can be acutely life-threatening. Treatment focuses on restoring normal blood calcium concentrations by calcium infusions, oral calcium supplements and vitamin D therapy.
Introduction and Index.
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